Adeno-Associated Viral Vectors for Gene Therapy by T.R. Flotte, and K.I. Berns (Eds.) PDF

By T.R. Flotte, and K.I. Berns (Eds.)

ISBN-10: 0444519491

ISBN-13: 9780444519498

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Safety testing Adventitious agents (in vitro and in vivo). These assays are designed to detect the presence of infectious viral agents of human or animal origin (serum, trypsin). Ch. 2 PRODUCTION OF RESEARCH AND CLINICAL AAV 35 Mycoplasma. The test for the presence of mycoplasma relies on expansion of cells in antibiotic‐free conditions and detection of the organism using dye or PCR, as well as growth of mycoplasma on appropriate agar media. Endotoxin. Endotoxin can be detected using the LAL or rabbit pyrogen assays.

Genetic analysis of adeno‐associated virus: Properties of deletion mutants constructed in vitro and evidence for an adeno‐associated virus replication function. J. Virol. 51, 611–619. Tratschin, J. , West, M. , Sandbank, T. and Carter, B. J. (1984). A human parvovirus, adeno‐associated virus, as a eucaryotic vector: Transient expression and encapsidation of the procaryotic gene for chloramphenicol acetyltransferase. Mol. Cell. Biol. 4, 2072–2081. , Ding, C. and Kotin, R. M. (2002). Insect cells as a factory to produce adeno‐associated virus type 2 vectors.

6, 986–993. Ch. 2 PRODUCTION OF RESEARCH AND CLINICAL AAV 51 Davidson, B. L. et al. (2000). Recombinant adeno‐associated virus type 2, 4, and 5 vectors: Transduction of variant cell types and regions in the mammalian central nervous system. Proc. Natl. Acad. Sci. USA 97, 3428–3432. Di Pasquale, G. and Stacey, S. N. (1998). Adeno‐associated virus Rep78 protein interacts with protein kinase A and its homolog PRKX and inhibits CREB‐dependent transcriptional activation. J. Virol. 72, 7916–7925. , Davidson, B.

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Adeno-Associated Viral Vectors for Gene Therapy by T.R. Flotte, and K.I. Berns (Eds.)

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