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Et al. (2009) An operational definition of epigenetics. Genes Dev. 23, 781– 783 2 Kouzarides, T. (2007) Chromatin modifications and their function. Cell 128, 693– 705 3 Cheng, X. M. (2010) Coordinated chromatin control: structural and functional linkage of DNA and histone methylation. Biochemistry 49, 2999– 3008 4 Ikegami, K. et al. (2009) Interplay between DNA methylation, histone modification and chromatin remodeling in stem cells and during development. Int. J. Dev. Biol. E. et al. (2006) A bivalent chromatin structure marks key developmental genes in embryonic stem cells.

And Weisburger, G. (1993) Chemical carcinogenesis. In Toxicology. The Basic Science of Poisons. McGraw-Hill 8 Beniashvili, D. (1994) Experimental Tumors in Monkeys. CRC Press 9 Rangarajan, A. A. (2003) Opinion: comparative biology of mouse versus human cells: modelling human cancer in mice. Nat. Rev. Cancer 3, 952–959 10 National Toxicology Program, (2004) A National Toxicology Program for the 21st Century: A Roadmap for the Future. J. et al. (2007) The ToxCast program for prioritizing toxicity testing of environmental chemicals.

A. O. et al. (2009) Cellular stress response pathway system as a sentinel ensemble in toxicological screening. Toxicol. Sci. R. J. (2008) Cellular oxygen sensing in health and disease. Pediatr. Nephrol. A. et al. (1996) Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. S. J. (2005) Targeting transcription factors for cancer therapy. Curr. Pharm. Des. O. (2009) Hypoxia response: a model toxicity pathway for highthroughput screening.

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