Case Files: Biochemistry (Lange Case Files), 2nd edition by Eugene C. Toy, Jr., William E Seifert, Henry W. Strobel, PDF

By Eugene C. Toy, Jr., William E Seifert, Henry W. Strobel, Konrad P. Harms

ISBN-10: 0071486658

ISBN-13: 9780071486651

ISBN-10: 0071643095

ISBN-13: 9780071643092

Fifty scientific instances assist you excel in biochemistry classes and the USMLE Step 1

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Extra info for Case Files: Biochemistry (Lange Case Files), 2nd edition

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The majority of circulating folate is in the form of N5-methyl THF. Cells use specific transporters for THF uptake, and cellular machinery polyglutamates the folate to aid in cellular retention. CLINICAL CASES 41 Figure 4-4. Intestinal absorption of dietary folates (THF-[Glu]n) and folic acid (F) from fortified cereal products and vitamin supplements. In the duodenum and upper jejunum, extra glutamate residues are cleaved by conjugases (γ-glutamyl carboxypeptidases). Folate (F) and reduced folate (THF) are absorbed by a proton-coupled, high affinity folate transporter into the mucosal cell, converted to N5-methyl THF and exported into the portal circulation.

1] A 44-year-old woman who recently lost her job because of absenteeism, presents to her physician complaining of loss of appetite, fatigue, muscle weakness, and emotional depression. The physical examination reveals a somewhat enlarged liver that feels firm and nodular, and there is a hint of jaundice in the sclerae and a hint of alcohol on her breath. The initial laboratory profile included a hematological analysis that showed that she had an anemia with enlarged red blood cells (macrocytic).

4] A female neonate is found to have a small spina bifida in her lower spinal column that could affect bladder and lower limb function. 1] E. Vitamin B12 is a cofactor in two biochemical reactions, the conversion of homocysteine to methionine by the enzyme methionine synthase and the conversion of L-methylmalonyl-CoA to succinylCoA by methylmalonyl-CoA mutase. N5-methyl THF is a methyl donor in the methionine synthase reaction. A folate deficiency would result in decreased methionine synthase activity and decreases in methionine and cystathionine concentrations, while homocysteine levels would be increased.

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Case Files: Biochemistry (Lange Case Files), 2nd edition by Eugene C. Toy, Jr., William E Seifert, Henry W. Strobel, Konrad P. Harms


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