By Mark L. Mayer, Ladislav Vyklicky Jr., Doris K. Patneau (auth.), Yehezkel Ben-Ari (eds.)
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Extra info for Excitatory Amino Acids and Neuronal Plasticity
R. Curtis, J. W. Phillis, and J. c. Watkins, The chemical excitation of spinal neurones by certain acidic amino acids, J. Physiol. 150:656 (1960). R. Dingledine, L. M. Boland, N. L. Chamberlin, K. Kawasaki, N. W. Kleckner, S. F. Traynelis, and T. A. Verdoorn, Amino acid receptors and uptake systems in the mammalian central nervous system, CRC CriL Rev. Neurobiol. 4:1 (1988). J. Elguero, C. Marzin, A. R. Katritzky, and P. Linda, The tautomerism of heterocycles, Adv. Heterocyclic Chem. Supp. 1 (1976).
The glycine binding site on NMDA receptors may tum out to have molecular similarity to the kainate-sensitive receptor, the glutamate binding site on the NMDA receptor, as well as to the inhibitory glycine receptor. The molecular resolution of EAA receptors is therefore likely to prove quite interesting. J 30 nA 300 JIM 3000 11M • • ;' o. &"'+15 11M CNQX .... & . ----'~---+-- -- - I -5 -4 -3 - I -2 log INMDAJ (M) 30 sec Fig. 8. 24 Non-competitive block of NMOA currents by CNQX. (A) Currents evoked by the indicated concentrations of NMDA in the absence (top) and presence (bottom) of 15 ~M CNQX.
From Kleckner and Dingledine, 1989. The most interesting finding was that every antagonist of the glycine site on NMDA receptors was shown also to be a kainate blocker (Fi~. 4). 1M 6,7-dichloro-3-hydroxy-2- quinoxaline carboxylic acid (6,7-diCl-HQC) produced a 45-fold parallel shift to the right of the glycine dose-response curve when the NMDA concentration was held constant (Fig. 50. 1M) glycine concentration (Fig. 50). A Schild plot (Fig. 10. 1M antagonist concentration) can be explained completely by competitive block of the glycine site.
Excitatory Amino Acids and Neuronal Plasticity by Mark L. Mayer, Ladislav Vyklicky Jr., Doris K. Patneau (auth.), Yehezkel Ben-Ari (eds.)